Gene information
Official symbol C5AR1
Official full name complement C5a receptor 1
Gene type protein-coding gene
Chromosome19q13.32
Alias symbolC5A; C5AR; CD88
Previous symbolC5R1
Gene familyComplement component GPCRs; CD molecules; Complement system regulators and receptors
Resources
Entrez Gene 728
HGNC HGNC:1338
Ensembl ENSG00000197405
Vega OTTHUMG00000183504
UCSC uc002pgj.2
GO terms: 34 records
GO Description Category LogP Number of genes Detail
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007202 activation of phospholipase C activity GO Biological Processes -4.61361828 8 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0021782 glial cell development GO Biological Processes -9.97103962 23 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0097242 amyloid-beta clearance GO Biological Processes -5.57650860 8 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1902622 regulation of neutrophil migration GO Biological Processes -4.86040077 10 More
GO:1902624 positive regulation of neutrophil migration GO Biological Processes -3.51698265 7 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
avacopan antagonist TTD view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
C5AR1 transcriptomics tocilizumab[treatment (pharmacotherapy)] acute non-ST elevation myocardial infarction Orrem HL et al. Front Immunol. 2018
C5AR1 transcriptomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Orrem HL et al. Front Immunol. 2018
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